IBM Grid Powers AIDS Breakthrough
IBM Grid Powers AIDS Breakthrough
Two Compounds Discovered By IBM's World Community Grid Will Pave The Way For New AIDS Drugs
Using the massive computational resources of the World Community Grid, a team of researchers at the renowned Scripps Research Institute has discovered two new compounds proving the existence of new binding sites on HIV protease, an enzyme used by the AIDS virus to create new, infectious viral particles. The results will enable the creation of a new class of more powerful drug treatments to fight HIV.
This experimental breakthrough, reported in the March cover story in the journal of Chemical Biology and Drug Design, will serve as the basis for new drug development to combat the increasing number of drug-resistant HIV strains, and also help to improve current AIDS therapies.
Associate Professor C. David Stout, senior author of the study, explained: "These results open the door to a whole new approach to drug design against HIV protease,"
Two members of the FightAIDS@Home team, Research Associate Alex Perryman, PhD, and Professor Arthur J Olson, were part of this innovative research and are now working to extend it.
"IBM's World Community Grid and its volunteers help us run millions of computations to evaluate the potential interactions between compounds and mutant viral proteins," said Prof Olson, who is Anderson Research Chair Professor, Department of Molecular Biology at The Scripps Research Institute.
According to the World Health Organization, about 33 million people now live with HIV. Several drugs that are now used to treat AIDS inhibit this HIV protease target, but drug-resistant mutants that impede the effectiveness of these drugs keep appearing and getting worse.
Using computing power from 1.5 million devices networked through IBM's grid, the new sites on the HIV protease are being used as docking targets for virtual screening experiments, in order to guide the development of these chemical compounds into a new class of potent HIV inhibitors
"World Community Grid speeds up humanitarian research by providing scientists with millions of dollars of supercomputer power, for free, that would otherwise not be available to them.
"Through this effort we were able to significantly speed up our investigation. Without the computational power of World Community Grid, it would have taken us many more years to get to this important step in our research," Dr Olson continued.
By aggregating the unused cycle time of 1.5 million personal computers donated by volunteers in over 80 countries, IBM's World Community Grid is now the world's largest public humanitarian grid, equivalent in power to a Top 10 supercomputer.
It has crunched more than 107,000 years of computational time in just 5 years for the Scripps Research Institute project, providing more than 104 million calculations.The team has already docked over 500,000 compounds against these newly characterized binding sites.
"The volunteers around the world who donate their computer time have helped usher in a potentially new class of drugs that may save lives and increase the quality of life for people living with HIV," said Dr. Joesph Jasinski, Distinguished Engineer and Program Director of IBM's Healthcare and Lifesciences Institute.
"World Community Grid enables a smarter way to conduct promising research by providing unprecedented computing power to projects that might not be positioned to make a difference in the world without access to a free supercomputer."
The FightAIDS@home project will continue to run calculations to further this research against drug-resistant mutant superbugs of HIV.
"In the fight against HIV/AIDS it is important to remind people that HIV has not gone away, and that there are many things still to be done," said Joe Solmonese, President of the Human Rights Campaign.
"World Community Grid is one way to get involved and makes it easy to contribute to this important research in a meaningful and effective way."
Once the HIV virus enters a human cell, it uses a small set of proteins called enzymes to force the cell to produce many new copies of itself, which then go on to infect other cells. Most HIV drugs work by blocking the operation of one or more of these enzymes. In the current work, the Scripps researchers are looking for new compounds that will stabilize the inhibited conformation, or shape, of the HIV protease enzyme, and thus help stop the virus from replicating.
Because HIV mutates so frequently, some drugs that inhibit the enzyme from replicating are no longer working, or are not working as effectively.
By running calculations on the World Community Grid FightAIDS@Home project, the team at Scripps is trying to develop new drugs that bind to more parts of the mutant enzyme, thereby shutting it down more effectively.
In a second paper recently published in the Journal of Molecular Biology, the Scripps team has used computational modeling to improve understanding of another HIV enzyme and key drug target - integrase. Integrase, along with protease and a third enzyme, reverse-transcriptase, is one of three key proteins that allow the HIV virus to take over the cellular machinery of the host cell and replicate itself.
By producing a more accurate model of integrase, the research allows further searches for new drug molecules that will inhibit the mutant drug resistant forms of this enzyme, as well. The Scripps team was recently awarded government stimulus funding as part of the American Recovery and Reinvestment Act to advance their new project against HIV integrase.
Donating your computer's spare cycle time to humanitarian research can help fight cancer , develop more nutritious rice or find more efficient energy sources, When your computer is idle, data is requested from World Community Grid's server to perform a computation. Once finished, the result is sent back to the server, prompting it for a new piece of work. It is not necessary to leave a computer on more than usual and encourage membersjust work as normal .
The grid harvests substantial computational power during a normal work day by taking advantage of the time when someone is on the phone, talking with colleagues, taking a coffee break or doing simple tasks that don't require the full power of the computer.
Other projects running on World Community Grid that have produced results include:
The Discovering Dengue Drugs Together project has identified potential antiviral compounds and is continuing with laboratory work on those.
The Nutritious Rice for the World project has returned 12 million transactions and 11,000 years of compute time.
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